Sunday, November 11, 2007

Prednisolone Vs Prednisone

UpToDate®: Glucocorticoid withdrawal: "The systemic bioavailability of prednisone is equivalent to that of prednisolone (0.77 to 0.80) [4]. Prednisone itself is biologically inactive, but it is rapidly converted to the active form prednisolone. However, patients with severe liver disease may have difficulty converting prednisone to prednisolone; in such patients, it is possible that one might not get the same effect from prednisone as from prednisolone. In addition, certain drug interactions can affect the metabolism and bioavailability of prednisone. As an example, barbiturates, phenytoin, or rifampin, attenuate the biological effects of glucocorticoids"